GOSH patient receives world-first treatment for her 'incurable' T-cell leukaemia

In 2021, Alyssa was diagnosed with T-cell acute lymphoblastic leukaemia (T-ALL) and received all current conventional therapies for her cancer, including chemotherapy and a bone marrow transplant. Unfortunately her disease came back and there were no further treatment options available as part of routine care.

Alyssa was the first patient to be enrolled onto a new clinical trial and in May she was admitted to the Bone Marrow Transplant (BMT) Unit at GOSH, to receive genetically modified CAR T-cells that originally came from a healthy donor. These cells had been edited using new base-editing technology to allow them to hunt down and kill the cancerous T-cells without attacking each other.

Just 28 days later, she was in remission and went on the receive a second bone marrow transplant to restore her immune system. Now, six-months post-BMT, she is doing well at home recovering with her family and continues her post-BMT follow-up at GOSH.