Devinsky O.
Cross J.H.
Laux L.
Marsh E.
Miller I.
Nabbout R.
Scheffer I.E.
Thiele E.A.
Wright S.
Cannabidiol in Dravet Syndrome Study Group Trial of cannabidiol for drug-resistant seizures in the Dravet syndrome. N. Engl. J. Med. 376 : 2011-2020 https://doi.org/10.1056/NEJMoa1611618 View in Article Scopus (837)
PubMed
Crossref
Google Scholar
Miller I.
Scheffer I.E.
Gunning B.
Sanchez-Carpintero R.
Gil-Nagel A.
Perry M.S.
Saneto R.P.
Checketts D.
Dunayevich E.
Knappertz V.
Group G.S. Dose-ranging effect of adjunctive oral cannabidiol vs placebo on convulsive seizure frequency in Dravet syndrome: A randomized clinical trial. JAMA Neurol. 77 : 613-621 https://doi.org/10.1001/jamaneurol.2020.0073 View in Article Scopus (103)
PubMed
Crossref
Google Scholar
Patra P.H.
Barker-Haliski M.
White H.S.
Whalley B.J.
Glyn S.
Sandhu H.
Jones N.
Bazelot M.
Williams C.M.
McNeish A.J. Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models. Epilepsia. 60 : 303-314 https://doi.org/10.1111/epi.14629 View in Article Scopus (78)
PubMed
Crossref
Google Scholar
Deiana S.
Watanabe A.
Yamasaki Y.
Amada N.
Arthur M.
Fleming S.
Woodcock H.
Dorward P.
Pigliacampo B.
Close S.
et al. Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Delta(9)-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour. Psychopharmacology. 219 : 859-873 https://doi.org/10.1007/s00213-011-2415-0 View in Article Scopus (222)
PubMed
Crossref
Google Scholar
Muir J.
Arancibia-Carcamo I.L.
MacAskill A.F.
Smith K.R.
Griffin L.D.
Kittler J.T. NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the gamma2 subunit. Proc. Natl. Acad. Sci. USA. 107 : 16679-16684 https://doi.org/10.1073/pnas.1000589107 View in Article Scopus (113)
PubMed
Crossref
Google Scholar
Kittler J.T.
Chen G.
Honing S.
Bogdanov Y.
McAinsh K.
Arancibia-Carcamo I.L.
Jovanovic J.N.
Pangalos M.N.
Haucke V.
Yan Z.
Moss S.J. Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc. Natl. Acad. Sci. USA. 102 : 14871-14876 https://doi.org/10.1073/pnas.0506653102 View in Article Scopus (138)
PubMed
Crossref
Google Scholar
Modebadze T.
Morgan N.H.
Pérès I.A.
Hadid R.D.
Amada N.
Hill C.
Williams C.
Stanford I.M.
Morris C.M.
Jones R.S.
et al. A low mortality, high morbidity reduced intensity status epilepticus (RISE) model of epilepsy and epileptogenesis in the rat. PLoS One. 11 : e0147265 https://doi.org/10.1371/journal.pone.0147265 View in Article Scopus (13)
PubMed
Crossref
Google Scholar
Wang J.
Liu S.
Haditsch U.
Tu W.
Cochrane K.
Ahmadian G.
Tran L.
Paw J.
Wang Y.
Mansuy I.
et al. Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses. J. Neurosci. 23 : 826-836 View in Article PubMed
Crossref
Google Scholar
Kneussel M.
Brandstätter J.H.
Laube B.
Stahl S.
Müller U.
Betz H. Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice. J. Neurosci. 19 : 9289-9297 View in Article PubMed
Crossref
Google Scholar
Essrich C.
Lorez M.
Benson J.A.
Fritschy J.M.
Lüscher B. Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin. Nat. Neurosci. 1 : 563-571 View in Article PubMed
Crossref
Google Scholar
Kreitzer A.C.
Regehr W.G. Cerebellar depolarization-induced suppression of inhibition is mediated by endogenous cannabinoids. J. Neurosci. 21 : RC174 View in Article PubMed
Crossref
Google Scholar
Llano I.
Marty A.
Armstrong C.M.
Konnerth A. Synaptic- and agonist-induced excitatory currents of Purkinje cells in rat cerebellar slices. J. Physiol. 434 : 183-213 View in Article PubMed
Crossref
Google Scholar
Fletcher-Jones A.
Hildick K.L.
Evans A.J.
Nakamura Y.
Henley J.M.
Wilkinson K.A. Protein interactors and trafficking pathways that regulate the cannabinoid Type 1 receptor (CB1R). Front. Mol. Neurosci. 13 : 108 https://doi.org/10.3389/fnmol.2020.00108 View in Article Scopus (10)
Crossref
Google Scholar
Bisogno T.
Hanus L.
De Petrocellis L.
Tchilibon S.
Ponde D.E.
Brandi I.
Moriello A.S.
Davis J.B.
Mechoulam R.
Di Marzo V. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br. J. Pharmacol. 134 : 845-852 https://doi.org/10.1038/sj.bjp.0704327 View in Article Scopus (812)
PubMed
Crossref
Google Scholar
De Petrocellis L.
Ligresti A.
Moriello A.S.
Allarà M.
Bisogno T.
Petrosino S.
Stott C.G.
Di Marzo V. Effects of cannabinoids and cannabinoid-enriched cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br. J. Pharmacol. 163 : 1479-1494 https://doi.org/10.1111/j.1476-5381.2010.01166.x View in Article Scopus (564)
PubMed
Crossref
Google Scholar
Rimmerman N.
Ben-Hail D.
Porat Z.
Juknat A.
Kozela E.
Daniels M.P.
Connelly P.S.
Leishman E.
Bradshaw H.B.
Shoshan-Barmatz V.
Vogel Z. Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death. Cell Death Dis. 4 : e949 https://doi.org/10.1038/cddis.2013.471 View in Article Scopus (102)
PubMed
Crossref
Google Scholar
Chamberland S.
Nebet E.
Rosenberg E.
Devinsky O.
Tsien R. Cannabidiol elevates the ratio of feedforward:feedback inhibition to dampen hippocampal activity propagation. Society for Neuroscience Annual Meeting, held in Chicago, United States. View in Article Google Scholar
Loup F.
Wieser H.G.
Yonekawa Y.
Aguzzi A.
Fritschy J.M. Selective alterations in GABAA receptor subtypes in human temporal lobe epilepsy. J. Neurosci. 20 : 5401-5419 View in Article PubMed
Crossref
Google Scholar
Wallace R.H.
Marini C.
Petrou S.
Harkin L.A.
Bowser D.N.
Panchal R.G.
Williams D.A.
Sutherland G.R.
Mulley J.C.
Scheffer I.E.
Berkovic S.F. Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nat. Genet. 28 : 49-52 https://doi.org/10.1038/ng0501-49 View in Article PubMed
Crossref
Google Scholar
Chuang S.H.
Westenbroek R.E.
Stella N.
Catterall W.A. Combined antiseizure efficacy of cannabidiol and clonazepam in a conditional mouse model of Dravet syndrome. J. J. Exp. Neurol. 2 : 81-85 https://doi.org/10.33696/neurol.2.040 View in Article PubMed
Crossref
Google Scholar