Bélanger M.
Allaman I.
Magistretti P.J. Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab. 14 : 724-738 https://doi.org/10.1016/j.cmet.2011.08.016 View in Article Google Scholar
Patel A.B.
Lai J.C.K.
Chowdhury G.M.I.
Hyder F.
Rothman D.L.
Shulman R.G.
Behar K.L. Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle. Proc. Natl. Acad. Sci. USA. 111 : 5385-5390 https://doi.org/10.1073/pnas.1403576111 View in Article Google Scholar
Lundgaard I.
Li B.
Xie L.
Kang H.
Sanggaard S.
Haswell J.D.R.
Sun W.
Goldman S.
Blekot S.
Nielsen M.
et al. Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism. Nat. Commun. 6 : 6807 https://doi.org/10.1038/ncomms7807 View in Article Google Scholar
Ivanov A.I.
Malkov A.E.
Waseem T.
Mukhtarov M.
Buldakova S.
Gubkina O.
Zilberter M.
Zilberter Y. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices. J. Cereb. Blood Flow Metab. 34 : 397-407 https://doi.org/10.1038/jcbfm.2013.222 View in Article Google Scholar
Maher F. Immunolocalization of GLUT1 and GLUT3 glucose transporters in primary cultured neurons and glia. J. Neurosci. Res. 42 : 459-469 https://doi.org/10.1002/jnr.490420404 View in Article Google Scholar
Ashrafi G.
Wu Z.
Farrell R.J.
Ryan T.A. GLUT4 mobilization supports energetic demands of active synapses. Neuron. 93 : 606-615.e3 https://doi.org/10.1016/j.neuron.2016.12.020 View in Article Google Scholar
Shin B.C.
Cepeda C.
Estrada-Sánchez A.M.
Levine M.S.
Hodaei L.
Dai Y.
Jung J.
Ganguly A.
Clark P.
Devaskar S.U. Neural deletion of glucose transporter isoform 3 creates distinct postnatal and adult neurobehavioral phenotypes. J. Neurosci. 38 : 9579-9599 https://doi.org/10.1523/JNEUROSCI.0503-18.2018 View in Article Google Scholar
Herrero-Mendez A.
Almeida A.
Fernández E.
Maestre C.
Moncada S.
Bolaños J.P. The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1. Nat. Cell Biol. 11 : 747-752 https://doi.org/10.1038/ncb1881 View in Article Google Scholar
Bolaños J.P.
Almeida A.
Moncada S. Glycolysis: a bioenergetic or a survival pathway?. Trends Biochem. Sci. 35 : 145-149 https://doi.org/10.1016/j.tibs.2009.10.006 View in Article Google Scholar
Rodriguez-Rodriguez P.
Fernandez E.
Almeida A.
Bolaños J.P. Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration. Cell Death Differ. 19 : 1582-1589 https://doi.org/10.1038/cdd.2012.33 View in Article Google Scholar
Burmistrova O.
Olias-Arjona A.
Lapresa R.
Jimenez-Blasco D.
Eremeeva T.
Shishov D.
Romanov S.
Zakurdaeva K.
Almeida A.
Fedichev P.O.
et al. Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice. Sci. Rep. 9 : 11670 https://doi.org/10.1038/s41598-019-48196-z View in Article Google Scholar
Lopez-Fabuel I.
Garcia-Macia M.
Buondelmonte C.
Burmistrova O.
Bonora N.
Alonso-Batan P.
Morant-Ferrando B.
Vicente-Gutierrez C.
Jimenez-Blasco D.
Quintana-Cabrera R.
et al. Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis. Nat. Commun. 13 : 536 https://doi.org/10.1038/s41467-022-28191-1 View in Article Google Scholar
Díaz-García C.M.
Mongeon R.
Lahmann C.
Koveal D.
Zucker H.
Yellen G. Neuronal stimulation triggers neuronal glycolysis and not lactate uptake. Cell Metab. 26 : 361-374.e4 https://doi.org/10.1016/j.cmet.2017.06.021 View in Article Google Scholar
Ardenkjaer-Larsen J.H.
Fridlund B.
Gram A.
Hansson G.
Hansson L.
Lerche M.H.
Servin R.
Thaning M.
Golman K. Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. Proc. Natl. Acad. Sci. USA. 100 : 10158-10163 https://doi.org/10.1073/pnas.1733835100 View in Article Google Scholar
Brindle K.M.
Bohndiek S.E.
Gallagher F.A.
Kettunen M.I. Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy. Magn. Reson. Med. 66 : 505-519 https://doi.org/10.1002/mrm.22999 View in Article Google Scholar
Chaumeil M.M.
Najac C.
Ronen S.M. Studies of metabolism using (13)C MRS of hyperpolarized probes. Methods Enzymol. 561 : 1-71 https://doi.org/10.1016/bs.mie.2015.04.001 View in Article Google Scholar
Nelson S.J.
Kurhanewicz J.
Vigneron D.B.
Larson P.E.Z.
Harzstark A.L.
Ferrone M.
van Criekinge M.
Chang J.W.
Bok R.
Park I.
et al. Metabolic imaging of patients with prostate cancer using hyperpolarized [1-(1)(3)C]pyruvate. Sci. Transl. Med. 5 : 198ra108 https://doi.org/10.1126/scitranslmed.3006070 View in Article Google Scholar
Gallagher F.A.
Woitek R.
McLean M.A.
Gill A.B.
Manzano Garcia R.
Provenzano E.
Riemer F.
Kaggie J.
Chhabra A.
Ursprung S.
et al. Imaging breast cancer using hyperpolarized carbon-13 MRI. Proc. Natl. Acad. Sci. USA. 117 : 2092-2098 https://doi.org/10.1073/pnas.1913841117 View in Article Google Scholar
Park I.
Larson P.E.Z.
Gordon J.W.
Carvajal L.
Chen H.Y.
Bok R.
Van Criekinge M.
Ferrone M.
Slater J.B.
Xu D.
et al. Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies. Magn. Reson. Med. 80 : 864-873 https://doi.org/10.1002/mrm.27077 View in Article Google Scholar
Wang C.
Ward M.E.
Chen R.
Liu K.
Tracy T.E.
Chen X.
Xie M.
Sohn P.D.
Ludwig C.
Meyer-Franke A.
et al. Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening. Stem Cell Rep. 9 : 1221-1233 https://doi.org/10.1016/j.stemcr.2017.08.019 View in Article Google Scholar
Zhang Y.
Pak C.
Han Y.
Ahlenius H.
Zhang Z.
Chanda S.
Marro S.
Patzke C.
Acuna C.
Covy J.
et al. Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron. 78 : 785-798 https://doi.org/10.1016/j.neuron.2013.05.029 View in Article Google Scholar
Tian R.
Gachechiladze M.A.
Ludwig C.H.
Laurie M.T.
Hong J.Y.
Nathaniel D.
Prabhu A.V.
Fernandopulle M.S.
Patel R.
Abshari M.
et al. CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons. Neuron. 104 : 239-255.e12 https://doi.org/10.1016/j.neuron.2019.07.014 View in Article Google Scholar
Bennett N.K.
Nguyen M.K.
Darch M.A.
Nakaoka H.J.
Cousineau D.
Ten Hoeve J.
Graeber T.G.
Schuelke M.
Maltepe E.
Kampmann M.
et al. Defining the ATPome reveals cross-optimization of metabolic pathways. Nat. Commun. 11 : 4319 https://doi.org/10.1038/s41467-020-18084-6 View in Article Google Scholar
Contat C.
Ancey P.B.
Zangger N.
Sabatino S.
Pascual J.
Escrig S.
Jensen L.
Goepfert C.
Lanz B.
Lepore M.
et al. Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. Elife. 9 : e53618 https://doi.org/10.7554/eLife.53618 View in Article Google Scholar
Horn K.E.
Glasgow S.D.
Gobert D.
Bull S.J.
Luk T.
Girgis J.
Tremblay M.E.
McEachern D.
Bouchard J.F.
Haber M.
et al. DCC expression by neurons regulates synaptic plasticity in the adult brain. Cell Rep. 3 : 173-185 https://doi.org/10.1016/j.celrep.2012.12.005 View in Article Google Scholar
Tsien J.Z.
Chen D.F.
Gerber D.
Tom C.
Mercer E.H.
Anderson D.J.
Mayford M.
Kandel E.R.
Tonegawa S. Subregion- and cell type-restricted gene knockout in mouse brain. Cell. 87 : 1317-1326 View in Article Google Scholar
Bergsman J.B.
Tsien R.W. Syntaxin modulation of calcium channels in cortical synaptosomes as revealed by botulinum toxin C1. J. Neurosci. 20 : 4368-4378 View in Article Google Scholar
Miller J.A.
Guillozet-Bongaarts A.
Gibbons L.E.
Postupna N.
Renz A.
Beller A.E.
Sunkin S.M.
Ng L.
Rose S.E.
Smith K.A.
et al. Neuropathological and transcriptomic characteristics of the aged brain. Elife. 6 : e31126 https://doi.org/10.7554/eLife.31126 View in Article Google Scholar
Lesburguères E.
Sparks F.T.
O'Reilly K.C.
Fenton A.A. Active place avoidance is no more stressful than unreinforced exploration of a familiar environment. Hippocampus. 26 : 1481-1485 https://doi.org/10.1002/hipo.22666 View in Article Google Scholar
Shields L.Y.
Kim H.
Zhu L.
Haddad D.
Berthet A.
Pathak D.
Lam M.
Ponnusamy R.
Diaz-Ramirez L.G.
Gill T.M.
et al. Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. Cell Death Dis. 6 : e1725 https://doi.org/10.1038/cddis.2015.94 View in Article Google Scholar
Marty S.
Peschanski M. Effects of target deprivation on the morphology and survival of adult dorsal column nuclei neurons. J. Comp. Neurol. 356 : 523-536 https://doi.org/10.1002/cne.903560404 View in Article Google Scholar
Li Z.
Okamoto K.I.
Hayashi Y.
Sheng M. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell. 119 : 873-887 View in Article Google Scholar
Tonegawa S.
Tsien J.Z.
McHugh T.J.
Huerta P.
Blum K.I.
Wilson M.A. Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning. Cold Spring Harb. Symp. Quant. Biol. 61 : 225-238 View in Article Google Scholar
Wang X.
Zhang C.
Szábo G.
Sun Q.Q. Distribution of CaMKIIalpha expression in the brain in vivo, studied by CaMKIIalpha-GFP mice. Brain Res. 1518 : 9-25 https://doi.org/10.1016/j.brainres.2013.04.042 View in Article Google Scholar
Semple B.D.
Blomgren K.
Gimlin K.
Ferriero D.M.
Noble-Haeusslein L.J. Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species. Prog. Neurobiol. 106-107 : 1-16 https://doi.org/10.1016/j.pneurobio.2013.04.001 View in Article Google Scholar
Tingley D.
McClain K.
Kaya E.
Carpenter J.
Buzsáki G. A metabolic function of the hippocampal sharp wave-ripple. Nature. 597 : 82-86 https://doi.org/10.1038/s41586-021-03811-w View in Article Google Scholar
Macdonald E.B.
Begovatz P.
Barton G.P.
Erickson-Bhatt S.
Inman D.R.
Cox B.L.
Eliceiri K.W.
Strigel R.M.
Ponik S.M.
Fain S.B. Hyperpolarized (13)C magnetic resonance spectroscopic imaging of pyruvate metabolism in murine breast cancer models of different metastatic potential. Metabolites. 11 : 274 https://doi.org/10.3390/metabo11050274 View in Article Google Scholar
Perkons N.R.
Kiefer R.M.
Noji M.C.
Pourfathi M.
Ackerman D.
Siddiqui S.
Tischfield D.
Profka E.
Johnson O.
Pickup S.
et al. Hyperpolarized metabolic imaging detects latent hepatocellular carcinoma domains surviving locoregional therapy. Hepatology. 72 : 140-154 https://doi.org/10.1002/hep.30970 View in Article Google Scholar
Varma G.
Seth P.
Coutinho de Souza P.
Callahan C.
Pinto J.
Vaidya M.
Sonzogni O.
Sukhatme V.
Wulf G.M.
Grant A.K. Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR. NMR Biomed. 34 : e4560 https://doi.org/10.1002/nbm.4560 View in Article Google Scholar
Guglielmetti C.
Najac C.
Didonna A.
Van der Linden A.
Ronen S.M.
Chaumeil M.M. Hyperpolarized (13)C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc. Natl. Acad. Sci. USA. 114 : E6982-E6991 https://doi.org/10.1073/pnas.1613345114 View in Article Google Scholar
Harris R.A.
Lone A.
Lim H.
Martinez F.
Frame A.K.
Scholl T.J.
Cumming R.C. Aerobic glycolysis is required for spatial memory acquisition but not memory retrieval in mice. eNeuro. 6 ( ) https://doi.org/10.1523/ENEURO.0389-18.2019 View in Article Google Scholar
Rao Y.
Gammon S.
Zacharias N.M.
Liu T.
Salzillo T.
Xi Y.
Wang J.
Bhattacharya P.
Piwnica-Worms D. Hyperpolarized [1-(13)C]pyruvate-to-[1-(13)C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane. Proc. Natl. Acad. Sci. USA. 117 : 22378-22389 https://doi.org/10.1073/pnas.2003537117 View in Article Google Scholar
Day S.E.
Kettunen M.I.
Gallagher F.A.
Hu D.E.
Lerche M.
Wolber J.
Golman K.
Ardenkjaer-Larsen J.H.
Brindle K.M. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nat. Med. 13 : 1382-1387 https://doi.org/10.1038/nm1650 View in Article Google Scholar
Witney T.H.
Kettunen M.I.
Day S.E.
Hu D.E.
Neves A.A.
Gallagher F.A.
Fulton S.M.
Brindle K.M. A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment. Neoplasia. 11 : 574-582 https://doi.org/10.1593/neo.09254 View in Article Google Scholar
Xie N.
Zhang L.
Gao W.
Huang C.
Huber P.E.
Zhou X.
Li C.
Shen G.
Zou B. NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct. Target. Ther. 5 : 227 https://doi.org/10.1038/s41392-020-00311-7 View in Article Google Scholar
Davidson S.M.
Schmidt D.R.
Heyman J.E.
O'Brien J.P.
Liu A.C.
Israelsen W.J.
Dayton T.L.
Sehgal R.
Bronson R.T.
Freinkman E.
et al. Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma. Cancer Res. 82 : 2403-2416 https://doi.org/10.1158/0008-5472.CAN-21-2352 View in Article Google Scholar
Zhang Y.
Chen K.
Sloan S.A.
Bennett M.L.
Scholze A.R.
O'Keeffe S.
Phatnani H.P.
Guarnieri P.
Caneda C.
Ruderisch N.
et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 34 : 11929-11947 https://doi.org/10.1523/JNEUROSCI.1860-14.2014 View in Article Google Scholar
Tech K.
Tikunov A.P.
Farooq H.
Morrissy A.S.
Meidinger J.
Fish T.
Green S.C.
Liu H.
Li Y.
Mungall A.J.
et al. Pyruvate kinase inhibits proliferation during postnatal cerebellar neurogenesis and suppresses medulloblastoma formation. Cancer Res. 77 : 3217-3230 https://doi.org/10.1158/0008-5472.CAN-16-3304 View in Article Google Scholar
Park I.
Mukherjee J.
Ito M.
Chaumeil M.M.
Jalbert L.E.
Gaensler K.
Ronen S.M.
Nelson S.J.
Pieper R.O. Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. Cancer Res. 74 : 7115-7124 https://doi.org/10.1158/0008-5472.CAN-14-0849 View in Article Google Scholar
Casson R.J.
Wood J.P.M.
Han G.
Kittipassorn T.
Peet D.J.
Chidlow G. M-Type pyruvate kinase isoforms and lactate dehydrogenase A in the mammalian retina: metabolic implications. Invest. Ophthalmol. Vis. Sci. 57 : 66-80 https://doi.org/10.1167/iovs.15-17962 View in Article Google Scholar
Pathak D.
Shields L.Y.
Mendelsohn B.A.
Haddad D.
Lin W.
Gerencser A.A.
Kim H.
Brand M.D.
Edwards R.H.
Nakamura K. The role of mitochondrially derived ATP in synaptic vesicle recycling. J. Biol. Chem. 290 : 22325-22336 https://doi.org/10.1074/jbc.M115.656405 View in Article Google Scholar
Rangaraju V.
Calloway N.
Ryan T.A. Activity-driven local ATP synthesis is required for synaptic function. Cell. 156 : 825-835 https://doi.org/10.1016/j.cell.2013.12.042 View in Article Google Scholar
Vannucci S.J.
Maher F.
Simpson I.A. Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia. 21 : 2-21 https://doi.org/10.1002/(sici)1098-1136 View in Article Google Scholar
Imamura H.
Nhat K.P.H.
Togawa H.
Saito K.
Iino R.
Kato-Yamada Y.
Nagai T.
Noji H. Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators. Proc. Natl. Acad. Sci. USA. 106 : 15651-15656 https://doi.org/10.1073/pnas.0904764106 View in Article Google Scholar
Mendelsohn B.A.
Bennett N.K.
Darch M.A.
Yu K.
Nguyen M.K.
Pucciarelli D.
Nelson M.
Horlbeck M.A.
Gilbert L.A.
Hyun W.
et al. A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. PLoS Biol. 16 : e2004624 https://doi.org/10.1371/journal.pbio.2004624 View in Article Google Scholar
Vona B.
Maroofian R.
Bellacchio E.
Najafi M.
Thompson K.
Alahmad A.
He L.
Ahangari N.
Rad A.
Shahrokhzadeh S.
et al. Expanding the clinical phenotype of IARS2-related mitochondrial disease. BMC Med. Genet. 19 : 196 https://doi.org/10.1186/s12881-018-0709-3 View in Article Google Scholar
Perli E.
Giordano C.
Tuppen H.A.L.
Montopoli M.
Montanari A.
Orlandi M.
Pisano A.
Catanzaro D.
Caparrotta L.
Musumeci B.
et al. Isoleucyl-tRNA synthetase levels modulate the penetrance of a homoplasmic m.4277T>C mitochondrial tRNA(Ile) mutation causing hypertrophic cardiomyopathy. Hum. Mol. Genet. 21 : 85-100 https://doi.org/10.1093/hmg/ddr440 View in Article Google Scholar
Ferdinandusse S.
Friederich M.W.
Burlina A.
Ruiter J.P.N.
Coughlin 2nd, C.R.
Dishop M.K.
Gallagher R.C.
Bedoyan J.K.
Vaz F.M.
Waterham H.R.
et al. Clinical and biochemical characterization of four patients with mutations in ECHS1. Orphanet J. Rare Dis. 10 : 79 https://doi.org/10.1186/s13023-015-0290-1 View in Article Google Scholar
Du J.
Li Z.
Li Q.Z.
Guan T.
Yang Q.
Xu H.
Pritchard K.A.
Camara A.K.S.
Shi Y. Enoyl coenzyme a hydratase domain-containing 2, a potential novel regulator of myocardial ischemia injury. J. Am. Heart Assoc. 2 : e000233 https://doi.org/10.1161/JAHA.113.000233 View in Article Google Scholar
Sharpe A.J.
McKenzie M. Mitochondrial fatty acid oxidation disorders associated with short-chain enoyl-CoA hydratase (ECHS1) deficiency. Cells. 7 : 46 https://doi.org/10.3390/cells7060046 View in Article Google Scholar
Sharkia I.
Hadad Erlich T.
Landolina N.
Assayag M.
Motzik A.
Rachmin I.
Kay G.
Porat Z.
Tshori S.
Berkman N.
et al. Pyruvate dehydrogenase has a major role in mast cell function, and its activity is regulated by mitochondrial microphthalmia transcription factor. J. Allergy Clin. Immunol. 140 : 204-214.e8 https://doi.org/10.1016/j.jaci.2016.09.047 View in Article Google Scholar
Guo W.
Ma J.
Yang Y.
Guo S.
Zhang W.
Zhao T.
Yi X.
Wang H.
Wang S.
Liu Y.
et al. ATP-citrate lyase epigenetically potentiates oxidative phosphorylation to promote melanoma growth and adaptive resistance to MAPK inhibition. Clin. Cancer Res. 26 : 2725-2739 https://doi.org/10.1158/1078-0432.CCR-19-1359 View in Article Google Scholar
Haq R.
Shoag J.
Andreu-Perez P.
Yokoyama S.
Edelman H.
Rowe G.C.
Frederick D.T.
Hurley A.D.
Nellore A.
Kung A.L.
et al. Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF. Cancer Cell. 23 : 302-315 https://doi.org/10.1016/j.ccr.2013.02.003 View in Article Google Scholar
Ferguson J.
Smith M.
Zudaire I.
Wellbrock C.
Arozarena I. Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth. Oncotarget. 8 : 32946-32959 https://doi.org/10.18632/oncotarget.16514 View in Article Google Scholar
Holden H.M.
Rayment I.
Thoden J.B. Structure and function of enzymes of the Leloir pathway for galactose metabolism. J. Biol. Chem. 278 : 43885-43888 https://doi.org/10.1074/jbc.R300025200 View in Article Google Scholar
Mueckler M.
Thorens B. The SLC2 (GLUT) family of membrane transporters. Mol. Aspects Med. 34 : 121-138 https://doi.org/10.1016/j.mam.2012.07.001 View in Article Google Scholar
Hamberger A.
Hyden H. Inverse enzymatic changes in neurons and glia during increased function and hypoxia. J. Cell Biol. 16 : 521-525 https://doi.org/10.1083/jcb.16.3.521 View in Article Google Scholar
Díaz-García C.M.
Meyer D.J.
Nathwani N.
Rahman M.
Martínez-François J.R.
Yellen G. The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle. Elife. 10 : e64821 https://doi.org/10.7554/eLife.64821 View in Article Google Scholar
Larson P.E.Z.
Gordon J.W. Hyperpolarized metabolic MRI-acquisition, reconstruction, and analysis methods. Metabolites. 11 : 386 https://doi.org/10.3390/metabo11060386 View in Article Google Scholar
Le Page L.M.
Guglielmetti C.
Taglang C.
Chaumeil M.M. Imaging brain metabolism using hyperpolarized (13)C magnetic resonance spectroscopy. Trends Neurosci. 43 : 343-354 https://doi.org/10.1016/j.tins.2020.03.006 View in Article Google Scholar
Zimmer E.R.
Parent M.J.
Souza D.G.
Leuzy A.
Lecrux C.
Kim H.I.
Gauthier S.
Pellerin L.
Hamel E.
Rosa-Neto P. [(18)F]FDG PET signal is driven by astroglial glutamate transport. Nat. Neurosci. 20 : 393-395 https://doi.org/10.1038/nn.4492 View in Article Google Scholar
Dayton T.L.
Gocheva V.
Miller K.M.
Israelsen W.J.
Bhutkar A.
Clish C.B.
Davidson S.M.
Luengo A.
Bronson R.T.
Jacks T.
Vander Heiden M.G. Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma. Genes Dev. 30 : 1020-1033 https://doi.org/10.1101/gad.278549.116 View in Article Google Scholar
Shin B.C.
Cepeda C.
Eghbali M.
Byun S.Y.
Levine M.S.
Devaskar S.U. Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders. Exp. Neurol. 338 : 113603 https://doi.org/10.1016/j.expneurol.2021.113603 View in Article Google Scholar
Goodpaster B.H.
Sparks L.M. Metabolic flexibility in health and disease. Cell Metab. 25 : 1027-1036 https://doi.org/10.1016/j.cmet.2017.04.015 View in Article Google Scholar
Motori E.
Atanassov I.
Kochan S.M.V.
Folz-Donahue K.
Sakthivelu V.
Giavalisco P.
Toni N.
Puyal J.
Larsson N.G. Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction. Sci. Adv. 6 : eaba8271 https://doi.org/10.1126/sciadv.aba8271 View in Article Google Scholar
Tramunt B.
Smati S.
Grandgeorge N.
Lenfant F.
Arnal J.F.
Montagner A.
Gourdy P. Sex differences in metabolic regulation and diabetes susceptibility. Diabetologia. 63 : 453-461 https://doi.org/10.1007/s00125-019-05040-3 View in Article Google Scholar
Du L.
Hickey R.W.
Bayir H.
Watkins S.C.
Tyurin V.A.
Guo F.
Kochanek P.M.
Jenkins L.W.
Ren J.
Gibson G.
et al. Starving neurons show sex difference in autophagy. J. Biol. Chem. 284 : 2383-2396 https://doi.org/10.1074/jbc.M804396200 View in Article Google Scholar
Christianto A.
Baba T.
Takahashi F.
Inui K.
Inoue M.
Suyama M.
Ono Y.
Ohkawa Y.
Morohashi K.I. Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle. Commun. Biol. 4 : 1264 https://doi.org/10.1038/s42003-021-02790-y View in Article Google Scholar
Levéen P.
Kotarsky H.
Mörgelin M.
Karikoski R.
Elmér E.
Fellman V. The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency: a viable mouse model for mitochondrial hepatopathy. Hepatology. 53 : 437-447 https://doi.org/10.1002/hep.24031 View in Article Google Scholar
Kotarsky H.
Keller M.
Davoudi M.
Levéen P.
Karikoski R.
Enot D.P.
Fellman V. Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation. PLoS One. 7 : e41156 https://doi.org/10.1371/journal.pone.0041156 View in Article Google Scholar
Purhonen J.
Grigorjev V.
Ekiert R.
Aho N.
Rajendran J.
Pietras R.
Truvé K.
Wikström M.
Sharma V.
Osyczka A.
et al. A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat. Commun. 11 : 322 https://doi.org/10.1038/s41467-019-14201-2 View in Article Google Scholar
Colville C.A.
Seatter M.J.
Jess T.J.
Gould G.W.
Thomas H.M. Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors. Biochem. J. 290 : 701-706 https://doi.org/10.1042/bj2900701 View in Article Google Scholar
Maher F.
Davies-Hill T.M.
Simpson I.A. Substrate specificity and kinetic parameters of GLUT3 in rat cerebellar granule neurons. Biochem. J. 315 : 827-831 https://doi.org/10.1042/bj3150827 View in Article Google Scholar
Reagan L.P.
Rosell D.R.
Alves S.E.
Hoskin E.K.
McCall A.L.
Charron M.J.
McEwen B.S. GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus. Brain Res. 932 : 129-134 https://doi.org/10.1016/s0006-8993(02)02308-9 View in Article Google Scholar
Simpson I.A.
Chundu K.R.
Davies-Hill T.
Honer W.G.
Davies P. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann. Neurol. 35 : 546-551 https://doi.org/10.1002/ana.410350507 View in Article Google Scholar
Manzo E.
Lorenzini I.
Barrameda D.
O'Conner A.G.
Barrows J.M.
Starr A.
Kovalik T.
Rabichow B.E.
Lehmkuhl E.M.
Shreiner D.D.
et al. Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS. Elife. 8 : e45114 https://doi.org/10.7554/eLife.45114 View in Article Google Scholar
Horlbeck M.A.
Gilbert L.A.
Villalta J.E.
Adamson B.
Pak R.A.
Chen Y.
Fields A.P.
Park C.Y.
Corn J.E.
Kampmann M.
Weissman J.S. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife. 5 : e19760 https://doi.org/10.7554/eLife.19760 View in Article Google Scholar
Chen E.Y.
Tan C.M.
Kou Y.
Duan Q.
Wang Z.
Meirelles G.V.
Clark N.R.
Ma'ayan A. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics. 14 : 128 https://doi.org/10.1186/1471-2105-14-128 View in Article Google Scholar
Kuleshov M.V.
Jones M.R.
Rouillard A.D.
Fernandez N.F.
Duan Q.
Wang Z.
Koplev S.
Jenkins S.L.
Jagodnik K.M.
Lachmann A.
et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 44 : W90-W97 https://doi.org/10.1093/nar/gkw377 View in Article Google Scholar
Xie Z.
Bailey A.
Kuleshov M.V.
Clarke D.J.B.
Evangelista J.E.
Jenkins S.L.
Lachmann A.
Wojciechowicz M.L.
Kropiwnicki E.
Jagodnik K.M.
et al. Gene set knowledge discovery with Enrichr. Curr. Protoc. 1 : e90 https://doi.org/10.1002/cpz1.90 View in Article Google Scholar
Berthet A.
Margolis E.B.
Zhang J.
Hsieh I.
Zhang J.
Hnasko T.S.
Ahmad J.
Edwards R.H.
Sesaki H.
Huang E.J.
Nakamura K. Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J. Neurosci. 34 : 14304-14317 https://doi.org/10.1523/JNEUROSCI.0930-14.2014 View in Article Google Scholar
Johnson E.C.B.
Ho K.
Yu G.Q.
Das M.
Sanchez P.E.
Djukic B.
Lopez I.
Yu X.
Gill M.
Zhang W.
et al. Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1. Mol. Neurodegener. 15 : 53 https://doi.org/10.1186/s13024-020-00393-5 View in Article Google Scholar
Arguello A.
Meisner R.
Thomsen E.R.
Nguyen H.N.
Ravi R.
Simms J.
Lo I.
Speckart J.
Holtzman J.
Gill T.M.
et al. Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome. JCI Insight. 6 : e145445 https://doi.org/10.1172/jci.insight.145445 View in Article Google Scholar
Xia Z.
Liu Y. Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. Biophys. J. 81 : 2395-2402 https://doi.org/10.1016/S0006-3495(01)75886-9 View in Article Google Scholar