Scarlets will give academy wing Callum Woolley his United Rugby Championship (URC) debut in Saturday's home game against Bulls (19:45 BST).
The 6ft 4in back has impressed for Carmarthen Quins in Super Rygbi Cymru and was called up by Great Britain 7s for the Singapore and Perth legs of the World Series in January.
The 20-year-old from Cardigan has been working in training with Wales and British and Irish Lions great Liam Williams, and he gets his chance on the right wing in place of Ellis Mee, who sustained an ankle injury in the loss to Cardiff last weekend.
There is also a change on the other wing with Macs Page starting in place of Tom Rogers, who is going through return-to-play head injury protocols.
In the centre, Joe Roberts gets the nod in the No 13 jersey, partnering Eddie James who moves to inside centre, while Joe Hawkins and Dane Blacker continue at half-back.
In the pack there is just one enforced change, with Wales prop Henry Thomas coming in at tight-head for Archer Holz, who is also recovering from a head knock.