Ivermectin’s popularity continued to climb in the pandemic’s second year. The podcaster Joe Rogan promoted it repeatedly on his shows. In a single week in August, U.S. insurance companies spent $2.4 million paying for ivermectin treatments
But not long after Dr. Hill published his review last summer, reports surfaced that many of the studies he included in the analysis were flawed and, in at least one case, alleged to be fraudulent. Dr. Hill retracted his original study and started a new one, which he published in January.
On their second review, Dr. Hill and his colleagues focused on the studies least likely to be biased. In that stricter survey, ivermectin’s benefit vanished.
Still, even the best studies on ivermectin and Covid were small, with a few hundred volunteers at most. Small studies can be vulnerable to statistical flukes that suggest positive effects where none actually exist. But larger studies on ivermectin were underway at the time, and those promised to be more rigorous.
In Brazil, researchers set up a clinical trial known as TOGETHER in June 2020 to test Covid patients with a number of widely used drugs, including ivermectin. The treatments were double-blinded, meaning that neither the patients nor their medical staff knew whether they received a Covid treatment drug or a placebo.
In one round of the trial, the researchers found promising evidence that an antidepressant drug called fluvoxamine reduced the need for hospitalization by one-third. The researchers published their results in October in The Lancet Global Health.
In a new study published on Wednesday, the TOGETHER team reported on its ivermectin data. Between March and August 2021, the researchers provided the drug to 679 patients over the course of three days.