Akira S.

Uematsu S.

Takeuchi O. Pathogen recognition and innate immunity. Cell. 124 : 783-801 View in Article Google Scholar

Ardigo D.

Assimes T.L.

Fortmann S.P.

Go A.S.

Hlatky M.

Hytopoulos E.

Iribarren C.

Tsao P.S.

Tabibiazar R.

Quertermous T.

ADVANCE Investigators Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease. Physiol. Genomics. 31 : 402-409 View in Article Google Scholar

Atakan Z. Cannabis, a complex plant: different compounds and different effects on individuals. Ther. Adv. Psychopharmacol. 2 : 241-254 View in Article Google Scholar

Baba O.

Huang L.H.

Elvington A.

Szpakowska M.

Sultan D.

Heo G.S.

Zhang X.

Luehmann H.

Detering L.

Chevigne A.

et al. CXCR4-binding positron emission tomography tracers link monocyte recruitment and endothelial injury in murine atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 41 : 822-836 View in Article Google Scholar

Badowski M.E. A review of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced nausea and vomiting: a focus on pharmacokinetic variability and pharmacodynamics. Cancer Chemother. Pharmacol. 80 : 441-449 View in Article Google Scholar

Baell J.B.

Holloway G.A. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. J. Med. Chem. 53 : 2719-2740 View in Article Google Scholar

Baron E.P. Comprehensive review of medicinal marijuana, cannabinoids, and therapeutic implications in medicine and headache: what a long strange trip it's been. Headache. 55 : 885-916 View in Article Google Scholar

Bayazit H.

Selek S.

Karababa I.F.

Cicek E.

Aksoy N. Evaluation of oxidant/antioxidant status and cytokine levels in patients with cannabis use disorder. Clin. Psychopharmacol. Neurosci. 15 : 237-242 View in Article Google Scholar

Bisson J.

Mcalpine J.B.

Friesen J.B.

Chen S.N.

Graham J.

Pauli G.F. Can invalid bioactives undermine natural product-based drug discovery?. J. Med. Chem. 59 : 1671-1690 View in Article Google Scholar

Boesten L.S.

Zadelaar A.S.

Van Nieuwkoop A.

Gijbels M.J.

De Winther M.P.

Havekes L.M.

Van Vlijmen B.J. Tumor necrosis factor-alpha promotes atherosclerotic lesion progression in APOE∗3-Leiden transgenic mice. Cardiovasc. Res. 66 : 179-185 View in Article Google Scholar

Brizzi M.F.

Formato L.

Dentelli P.

Rosso A.

Pavan M.

Garbarino G.

Pegoraro M.

Camussi G.

Pegoraro L. Interleukin-3 stimulates migration and proliferation of vascular smooth muscle cells: a potential role in atherogenesis. Circulation. 103 : 549-554 View in Article Google Scholar

Bycroft C.

Freeman C.

Petkova D.

Band G.

Elliott L.T.

Sharp K.

Motyer A.

Vukcevic D.

Delaneau O.

O'Connell J.

et al. The UK biobank resource with deep phenotyping and genomic data. Nature. 562 : 203-209 View in Article Google Scholar

Cavusoglu E.

Marmur J.D.

Yanamadala S.

Chopra V.

Hegde S.

Nazli A.

Singh K.P.

Zhang M.

Eng C. Elevated baseline plasma IL-8 levels are an independent predictor of long-term all-cause mortality in patients with acute coronary syndrome. Atherosclerosis. 242 : 589-594 View in Article Google Scholar

Cerdá M.

Mauro C.

Hamilton A.

Levy N.S.

Santaella-Tenorio J.

Hasin D.

Wall M.M.

Keyes K.M.

Martins S.S. Association Between recreational marijuana legalization in the United States and changes in marijuana use and cannabis use disorder From 2008 to 2016. JAMA Psychiatry. 77 : 165-171 View in Article Google Scholar

Chang T.T.

Yang H.Y.

Chen C.

Chen J.W. CCL4 inhibition in atherosclerosis: effects on plaquestability, endothelial cell adhesiveness, and macrophages activation. Int. J. Mol. Sci. 21 : 6567 View in Article Google Scholar

Chen P.Y.

Qin L.

Li G.

Wang Z.

Dahlman J.E.

Malagon-Lopez J.

Gujja S.

Cilfone N.A.

Kauffman K.J.

Sun L.

et al. Endothelial TGF-beta signalling drives vascular inflammation and atherosclerosis. Nat. Metab. 1 : 912-926 View in Article Google Scholar

Choi J.H.

Cheong C.

Dandamudi D.B.

Park C.G.

Rodriguez A.

Mehandru S.

Velinzon K.

Jung I.H.

Yoo J.Y.

Oh G.T.

Steinman R.M. Flt3 signaling-dependent dendritic cells protect against atherosclerosis. Immunity. 35 : 819-831 View in Article Google Scholar

Cinar R.

Iyer M.R.

Kunos G. The therapeutic potential of second and third generation CB1R antagonists. Pharmacol. Ther. 208 : 107477 View in Article Google Scholar

Cotter J. Efficacy of crude marijuana and synthetic Delta-9-tetrahydro cannabinol as treatment for chemotherapy-induced nausea and vomiting: A systematic literature review. Oncol. Nurs. Forum. 36 : 345-352 View in Article Google Scholar

Damås J.K.

Smith C.

Øie E.

Fevang B.

Halvorsen B.

Waehre T.

Boullier A.

Breland U.

Yndestad A.

Ovchinnikova O.

et al. Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization. Arterioscler. Thromb. Vasc. Biol. 27 : 614-620 View in Article Google Scholar

Defilippis E.M.

Singh A.

Divakaran S.

Gupta A.

Collins B.L.

Biery D.

Qamar A.

Fatima A.

Ramsis M.

Pipilas D.

et al. Cocaine and marijuana use among young adults with myocardial infarction. J. Am. Coll. Cardiol. 71 : 2540-2551 View in Article Google Scholar

Després J.P.

Golay A.

Sjöström L.

Rimonabant in Obesity-Lipids Study Group Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N. Engl. J. Med. 353 : 2121-2134 View in Article Google Scholar

DiMarzo V.

Fontana A.

Cadas H.

Schinelli S.

Cimino G.

Schwartz J.C.

Piomelli D. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature. 372 : 686-691 View in Article Google Scholar

El-Remessy A.B.

Rajesh M.

Mukhopadhyay P.

Horvath B.

Patel V.

Al-Gayyar M.M.

Pillai B.A.

Pacher P. Cannabinoid 1 receptor activation contributes to vascular inflammation and cell death in a mouse model of diabetic retinopathy and a human retinal cell line. Diabetologia. 54 : 1567-1578 View in Article Google Scholar

Förstermann U.

Sessa W.C. Nitric oxide synthases: regulation and function. Eur. Heart J. 33 : 829-837 View in Article Google Scholar

Fride E.

Perchuk A.

Hall F.S.

Uhl G.R.

Onaivi E.S. Behavioral methods in cannabinoid research. Methods Mol. Med. 123 : 269-290 View in Article Google Scholar

Friesner R.A.

Murphy R.B.

Repasky M.P.

Frye L.L.

Greenwood J.R.

Halgren T.A.

Sanschagrin P.C.

Mainz D.T. Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes. J.Med.Chem. 49 : 6177-6196 View in Article Google Scholar

Gleason C.E.

Carlsson C.M.

Barnet J.H.

Meade S.A.

Setchell K.D.

Atwood C.S.

Johnson S.C.

Ries M.L.

Asthana S. A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women. Age Ageing. 38 : 86-93 View in Article Google Scholar

Gregorio G.G.

Masureel M.

Hilger D.

Terry D.S.

Juette M.

Zhao H.

Zhou Z.

Perez-Aguilar J.M.

Hauge M.

Mathiasen S.

et al. Single-molecule analysis of ligand efficacy in beta2AR-G-protein activation. Nature. 547 : 68-73 View in Article Google Scholar

Gurley R.J.

Aranow R.

Katz M. Medicinal marijuana: a comprehensive review. J.Psychoactive Drugs. 30 : 137-147 View in Article Google Scholar

Halgren T.A.

Murphy R.B.

Friesner R.A.

Beard H.S.

Frye L.L.

Pollard W.T.

Banks J.L. Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening. J. Med. Chem. 47 : 1750-1759 View in Article Google Scholar

Heitzer T.

Schlinzig T.

Krohn K.

Meinertz T.

Münzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation. 104 : 2673-2678 View in Article Google Scholar

Heller E.A.

Liu E.

Tager A.M.

Yuan Q.

Lin A.Y.

Ahluwalia N.

Jones K.

Koehn S.L.

Lok V.M.

Aikawa E.

et al. Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation. 113 : 2301-2312 View in Article Google Scholar

Hill K.P.

Palastro M.D.

Johnson B.

Ditre J.W. Cannabis and pain: A clinical review. Cannabis Cannabinoid Res. 2 : 96-104 View in Article Google Scholar

Hoffman A.F.

Lupica C.R. Synaptic targets of Δ9-tetrahydrocannabinol in the central nervous system. Cold Spring Harb. Perspect. Med. 3 : a012237 View in Article Google Scholar

Huestis M.A.

Cone E.J. Relationship of Delta 9-tetrahydro cannabinol concentrations in oral fluid and plasma after controlled administration of smoked cannabis. J. Anal. Toxicol. 28 : 394-399 View in Article Google Scholar

Ibsen M.S.

Connor M.

Glass M. Cannabinoid CB1 and CB2 receptor signaling and bias. Cannabis Cannabinoid Res. 2 : 48-60 View in Article Google Scholar

Jia Z.

Babu P.V.

Si H.

Nallasamy P.

Zhu H.

Zhen W.

Misra H.P.

Li Y.

Liu D. Genistein inhibits TNF-alpha-induced endothelial inflammation through the protein kinase pathway A and improves vascular inflammation in C57BL/6 mice. Int. J. Cardiol. 168 : 2637-2645 View in Article Google Scholar

Klein T.W.

Newton C.A. Therapeutic potential of cannabinoid-based drugs. Adv.Exp.Med.Biol. 601 : 395-413 View in Article Google Scholar

KrishnaKumar K.

Shalev-Benami M.

Robertson M.J.

Hu H.

Banister S.D.

Hollingsworth S.A.

Latorraca N.R.

Kato H.E.

Hilger D.

Maeda S.

et al. Structure of a signaling cannabinoid receptor 1-G protein complex. Cell. 176 : 448-458.e12 View in Article Google Scholar

Kwon Y.D.

Byun Y.

Kim H.K. 18F-labelled BODIPY dye as a dual imaging agent: Radiofluorination and applications in PET and optical imaging. Nucl. Med. Biol. 93 : 22-36 View in Article Google Scholar

Lau E.

Paik D.T.

Wu J.C. Systems-wide approaches in induced pluripotent stem cell models. Annu. Rev. Pathol. 14 : 395-419 View in Article Google Scholar

Lee J.

Termglinchan V.

Diecke S.

Itzhaki I.

Lam C.K.

Garg P.

Lau E.

Greenhaw M.

Seeger T.

Wu H.

et al. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature. 572 : 335-340 View in Article Google Scholar

Li C.

Liu Z.H.

Chen J.W.

Shu X.Y.

Shen Y.

Ding F.H.

Zhang R.Y.

Shen W.F.

Lu L.

Wang X.Q. Using enface immunofluorescence staining to observe vascular endothelial cells directly. J. Vis. Exp. 150 View in Article Google Scholar

Little P.J.

Compton D.R.

Johnson M.R.

Melvin L.S.

Martin B.R. Pharmacology and stereo selectivity of structurally novel cannabinoids in mice. J.Pharmacol. Exp.Ther. 247 : 1046-1051 View in Article Google Scholar

Liu J.

Gao B.

Mirshahi F.

Sanyal A.J.

Khanolkar A.D.

Makriyannis A.

Kunos G. Functional CB1 cannabinoid receptors in human vascular endothelial cells. Biochem. J. 346 : 835-840 View in Article Google Scholar

Lynch K.L.

Luo Y.R.

Hooshfar S.

Yun C. Correlation of breath and blood Δ9-tetrahydro cannabinol concentrations and release kinetics following controlled administration of smoked cannabis. Clin. Chem. 65 : 1171-1179 View in Article Google Scholar

Mackie K. Cannabinoid receptors as therapeutic targets. Annu. Rev. Pharmacol. Toxicol. 46 : 101-122 View in Article Google Scholar

Mandegar M.A.

Huebsch N.

Frolov E.B.

Shin E.

Truong A.

Olvera M.P.

Chan A.H.

Miyaoka Y.

Holmes K.

Spencer C.I.

et al. CRISPR interference efficiently induces specific and reversible gene silencing in human iPSCs. Cell Stem Cell. 18 : 541-553 View in Article Google Scholar

Mattioli I.

Sebald A.

Bucher C.

Charles R.P.

Nakano H.

Doi T.

Kracht M.

Schmitz M.L. Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import. J. Immunol. 172 : 6336-6344 View in Article Google Scholar

Mckellar G.E.

Mccarey D.W.

Sattar N.

Mcinnes I.B. Role for TNF in atherosclerosis? Lessons from autoimmune disease. Nat. Rev. Cardiol. 6 : 410-417 View in Article Google Scholar

Mestas J.

Ley K. Monocyte-endothelial cell interactions in the development of atherosclerosis. Trends Cardiovasc. Med. 18 : 228-232 View in Article Google Scholar

Moreira F.A.

Grieb M.

Lutz B. Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression. Best Pract. Res. Clin. Endocrinol. Metab. 23 : 133-144 View in Article Google Scholar

Moshiri J.

Constant D.A.

Liu B.

Mateo R.

Kearnes S.

Novick P.

Prasad R.

Nagamine C.

Pande V.

Kirkegaard K. A targeted computational screen of the SWEETLEAD database reveals FDA-approved compounds with anti-dengue viral activity. mBio. 11 ( ) View in Article Google Scholar

Movahed P.

Evilevitch V.

Andersson T.L.

Jönsson B.A.

Wollmer P.

Zygmunt P.M.

Högestätt E.D. Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation. Br. J. Pharmacol. 146 : 171-179 View in Article Google Scholar

Mukhopadhyay P.

Rajesh M.

Bátkai S.

Patel V.

Kashiwaya Y.

Liaudet L.

Evgenov O.V.

Mackie K.

Haskó G.

Pacher P. CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. Cardiovasc. Res. 85 : 773-784 View in Article Google Scholar

Nagarkatti P.

Pandey R.

Rieder S.A.

Hegde V.L.

Nagarkatti M. Cannabinoids as novel anti-inflammatory drugs. Future Med.Chem. 1 : 1333-1349 View in Article Google Scholar

Nam D.

Ni C.W.

Rezvan A.

Suo J.

Budzyn K.

Llanos A.

Harrison D.

Giddens D.

Jo H. Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis. Am. J. Physiol. Heart Circ. Physiol. 297 : H1535-H1543 View in Article Google Scholar

Onakpoya I.J.

Heneghan C.J.

Aronson J.K. Worldwide withdrawal of medicinal products because of adverse drug reactions: a systematic review and analysis. Crit. Rev. Toxicol. 46 : 477-489 View in Article Google Scholar

Pacher P.

Mechoulam R. Is lipid signaling through cannabinoid 2 receptors part of a protective system?. Prog. Lipid Res. 50 : 193-211 View in Article Google Scholar

Pacher P.

Steffens S.

Haskó G.

Schindler T.H.

Kunos G. Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly. Nat. Rev. Cardiol. 15 : 151-166 View in Article Google Scholar

Paik D.T.

Tian L.

Lee J.

Sayed N.

Chen I.Y.

Rhee S.

Rhee J.W.

Kim Y.

Wirka R.C.

Buikema J.W.

et al. Large-scale single-cell RNA-Seq reveals molecular signatures of heterogeneous populations of human induced pluripotent stem cell-derived endothelial cells. Circ. Res. 123 : 443-450 View in Article Google Scholar

Paramel G.V.

Karadimou G.

Eremo A.G.

Ljungberg L.U.

Hedin U.

Olofsson P.S.

Folkersen L.

Paulsson-Berne G.

Sirsjö A.

Fransén K. Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells. Sci. Rep. 10 : 19108 View in Article Google Scholar

Park J.G.

Yoo J.Y.

Jeong S.J.

Choi J.H.

Lee M.R.

Lee M.N.

Hwa Lee J.

Kim H.C.

Jo H.

Yu D.Y.

et al. Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice. Circ.Res. 109 : 739-749 View in Article Google Scholar

Pertwee R.G.

Howlett A.C.

Abood M.E.

Alexander S.P.

DiMarzo V.

Elphick M.R.

Greasley P.J.

Hansen H.S.

Kunos G.

Mackie K.

et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol. Rev. 62 : 588-631 View in Article Google Scholar

Pope 3rd, C.A.

Burnett R.T.

Thurston G.D.

Thun M.J.

Calle E.E.

Krewski D.

Godleski J.J. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation. 109 : 71-77 View in Article Google Scholar

Rajesh M.

Bátkai S.

Kechrid M.

Mukhopadhyay P.

Lee W.S.

Horváth B.

Holovac E.

Cinar R.

Liaudet L.

Mackie K.

et al. Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. Diabetes. 61 : 716-727 View in Article Google Scholar

Rajesh M.

Mukhopadhyay P.

Bátkai S.

Patel V.

Saito K.

Matsumoto S.

Kashiwaya Y.

Horváth B.

Mukhopadhyay B.

Becker L.

et al. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J. Am. Coll. Cardiol. 56 : 2115-2125 View in Article Google Scholar

Rajesh M.

Mukhopadhyay P.

Haskó G.

Liaudet L.

Mackie K.

Pacher P. Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells. Br. J. Pharmacol. 160 : 688-700 View in Article Google Scholar

Ridker P.M.

Libby P.

Macfadyen J.G.

Thuren T.

Ballantyne C.

Fonseca F.

Koenig W.

Shimokawa H.

Everett B.M.

Glynn R.J. Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: analyses from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). Eur. Heart J. 39 : 3499-3507 View in Article Google Scholar

Ritchie M.E.

Phipson B.

Wu D.

Hu Y.

Law C.W.

Shi W.

Smyth G.K. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43 : e47 View in Article Google Scholar

Saha R.N.

Jana M.

Pahan K. MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65. J. Immunol. 179 : 7101-7109 View in Article Google Scholar

Sanberg P.R.

Bunsey M.D.

Giordano M.

Norman A.B. The catalepsy test: its ups and downs. Behav.Neurosci. 102 : 748-759 View in Article Google Scholar

Shi Y.

Inoue H.

Wu J.C.

Yamanaka S. Induced pluripotent stem cell technology: a decade of progress. Nat. Rev. Drug Discov. 16 : 115-130 View in Article Google Scholar

Sugamura K.

Sugiyama S.

Nozaki T.

Matsuzawa Y.

Izumiya Y.

Miyata K.

Nakayama M.

Kaikita K.

Obata T.

Takeya M.

Ogawa H. Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages. Circulation. 119 : 28-36 View in Article Google Scholar

Sun B.B.

Maranville J.C.

Peters J.E.

Stacey D.

Staley J.R.

Blackshaw J.

Burgess S.

Jiang T.

Paige E.

Surendran P.

et al. Genomic atlas of the human plasma proteome. Nature. 558 : 73-79 View in Article Google Scholar

Szentes V.

Gazdag M.

Szokodi I.

Dézsi C.A. The role of CXCR3 and associated chemokines in the development of atherosclerosis and During myocardial infarction. Front. Immunol. 9 : 1932 View in Article Google Scholar

Thomas G.

Kloner R.A.

Rezkalla S. Adverse cardiovascular, cerebrovascular, and peripheral vascular effects of marijuana inhalation: what cardiologists need to know. Am. J. Cardiol. 113 : 187-190 View in Article Google Scholar

Wang X.

Derakhshandeh R.

Liu J.

Narayan S.

Nabavizadeh P.

Le S.

Danforth O.M.

Pinnamaneni K.

Rodriguez H.J.

Luu E.

et al. One minute of marijuana second hand smoke exposure substantially impairs vascular endothelial function. J. Am. Heart Assoc. 5 View in Article Google Scholar

Welsh P.

Murray H.M.

Ford I.

Trompet S.

DeCraen A.J.

Jukema J.W.

Stott D.J.

Mcinnes I.B.

Packard C.J.

Westendorp R.G.

et al. Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk. Arterioscler.Thromb.Vasc.Biol. 31 : 2338-2344 View in Article Google Scholar

Whiting P.F.

Wolff R.F.

Deshpande S.

DiNisio M.

Duffy S.

Hernandez A.V.

Keurentjes J.C.

Lang S.

Misso K.

Ryder S.

et al. Cannabinoids for medical use: a systematic review and meta-analysis. JAMA. 313 : 2456-2473 View in Article Google Scholar

Wiley J.L.

Martin B.R. Cannabinoid pharmacological properties common to other centrally acting drugs. Eur. J. Pharmacol. 471 : 185-193 View in Article Google Scholar

Yang Z.

Kulkarni K.

Zhu W.

Hu M. Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME. Anticancer. Agents Med. Chem. 12 : 1264-1280 View in Article Google Scholar

Yun T.J.

Lee J.S.

Shim D.

Choi J.H.

Cheong C. Isolation and characterization of aortic dendritic cells and lymphocytes in atherosclerosis. Methods Mol. Biol. 1559 : 419-437 View in Article Google Scholar