1Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA

2Department of Social and Behavioral Science, Harvard TH Chan School of Public Health, Boston, MA

3Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA

4Division of Women's Health, Brigham and Women's Hospital, Boston, MA

5Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Boston, MA

6Department of Psychiatry, Brigham and Women's Hospital, Boston, MA

7Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO

8Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Boston, MA

9Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA

10Diabetes Unit, Massachusetts General Hospital, Boston, MA.

Received May 18, 2022; revised and accepted June 23, 2022.

Funding/support: This work was supported by the National Institutes of Health (grants R01HD096032, U54AG062322, R01034568) and the Harvard Pilgrim Health Care Institute. S.F. is supported by a postdoctoral fellowship award from the Fonds de recherche du Québec-Société et culture. W.P. is supported by a CCTSI KL2-TR002534 award.

Financial disclosure/conflicts of interest: H.J. reports the following relationships (over the past 12 months): grant support from National Institutes of Health, Merck, Pfizer. Consultant and advisory fees from Eisai, Jazz, Bayer. Funding to institution from NeRRe/KANDy, Que-Oncology. Spouse is an employee of Arsenal Biosciences; Spouse has an equity stake in Merck Research Labs and Tango Therapeutics. E.O. receives funding from UpToDate. The other authors have nothing to disclose.

Supplemental digital content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal’s Website (www.menopause.org).

Address correspondence to: Sabrina Faleschini, Ph.D., Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute Landmark Center, Suite 401, 401 Park Drive, East Boston, MA 02215. E-mail: [email protected]